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Benzene-d6

99.5 atom%D

Item number1040
CAS1076-43-3
FormulaC6D6
Molecular weight84,15 g/mol
Quantity 10x0.75ml
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Safety Data Sheetaccording to Regulation (EC) No 1907/2006 (REACH)
Classifications according to Regulation (EC) No 1272/2008.
Printdate 17.09.2021
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product name:Benzene-d6
Catalog No.:1040
Relevant identified uses of the substance or mixtureIdentified: Laboratory chemical
uses: R&D
Uses advised against:HPC Standards GmbH
Permoserstrasse 15

04318 Leipzig
Germany

Tel. +49 341 5295 183
Fax. +49 341 5295 182
E-mail: info@armar-europa.de
HAZARDS IDENTIFICATION2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Flammable liquids (Category 2), H225
Skin irritation (Category 2), H315
Eye irritation (Category 2), H319
Germ cell mutagenicity (Category 1B), H340
Carcinogenicity (Category 1A), H350
Specific target organ toxicity - repeated exposure (Category 1), H372
Aspiration hazard (Category 1), H304
Long-term (chronic) aquatic hazard (Category 3), H412
Label elements
Pictogramflamme
flamme
GHS07 exclam
exclam
GHS08 silhouete
silhouete
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram Signal word Danger
Hazard statement(s)
H225 Highly flammable liquid and vapor.
H304 May be fatal if swallowed and enters airways.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H340 May cause genetic defects.
H350 May cause cancer.
H372 Causes damage to organs through prolonged or repeated
exposure.
H412 Harmful to aquatic life with long lasting effects.
Precautionary statement(s)
P201 Obtain special instructions before use.
P210 Keep away from heat, hot surfaces, sparks, open flames and
other ignition sources. No smoking.
P273 Avoid release to the environment.
P301 + P310 + P331 IF SWALLOWED: Immediately call a POISON CENTER/doctor. Do
NOT induce vomiting.
P302 + P352 IF ON SKIN: Wash with plenty of water.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
Supplemental Hazard
Statements
none
Restricted to professional users.
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
COMPOSITION/INFORMATION ON INGREDIENTS3.1 Substances
Synonyms : Hexadeuterobenzene
Formula : C6D6
Molecular weight : 84,15 g/mol
CAS-No. : 1076-43-3
EC-No. : 214-061-8
Component Classification Concentration
(2H6)benzene
Flam. Liq. 2; Skin Irrit. 2;
Eye Irrit. 2; Muta. 1B;
Carc. 1A; STOT RE 1; Asp.
Tox. 1; Aquatic Chronic 3;
<= 100 % H225, H315, H319, H340,
H350, H372, H304, H412
FormulaC6D6
Molecular Weight (g/mol)84.15
CAS-No.1076-43-3
FIRST AID MEASURES4.1 Description of first-aid measures
General advice
Consult a physician. Show this material safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a
physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse
mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
FIRE-FIGHTING MEASURES5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
Use water spray to cool unopened containers
ACCIDENTAL RELEASE MEASURES6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate
ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of
vapors accumulating to form explosive concentrations. Vapors can accumulate in low
areas. For personal protection see section 8.
6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Discharge into the environment must be avoided.
6.3 Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wetbrushing
and place in container for disposal according to local regulations (see section
13).
6.4 Reference to other sections
For disposal see section 13.
HANDLING AND STORAGE7.1 Precautions for safe handling
Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes.
Avoid inhalation of vapor or mist.
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of
electrostatic charge.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent
leakage.
Handle and store under inert gas. Hygroscopic.
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
EXPOSURE CONTROLS/PERSONAL PROTECTION8.1 Control parameters Components with workplace control parameters 8.2 Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment

Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching gloves outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it. If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
PHYSICAL AND CHEMICAL PROPERTIES9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid
Color: colorless
b) Odor No data available
c) Odor Threshold No data available
d) pH No data available
e) Melting
point/freezing point
Melting point/range: 6,8 °C - lit.
f) Initial boiling point
and boiling range
79,1 °C at 1.013 hPa - lit. g) Flash point -11 °C - closed cup
h) Evaporation rate No data available
i) Flammability (solid,
gas)
No data available
j) Upper/lower
flammability or
explosive limits
Upper explosion limit: 8 %(V)
Lower explosion limit: 1,3 %(V)
k) Vapor pressure 221 hPa at 37,7 °C
99,5 hPa at 20 °C
l) Vapor density 2,91 - (Air = 1.0)
m) Relative density 0,95 g/cm3 at 25 °C
n) Water solubility No data available
o) Partition coefficient:
n-octanol/water
log Pow: 2,13 at 25 °C
p) Autoignition
temperature
No data available
q) Decomposition
temperature
No data available
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
Relative vapor
density
2,91 - (Air = 1.0)
STABILITY AND REACTIVITY10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
No data available
10.4 Conditions to avoid
Heat, flames and sparks.
10.5 Incompatible materials
Acids, Bases, Halogens, Strong oxidizing agents, metal salts
10.6 Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides
Other decomposition products - No data available
In the event of fire: see section 5
TOXICOLOGICAL INFORMATION11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male - > 2.000 mg/kg
(OECD Test Guideline 401)
LC50 Inhalation - Rat - female - 4 h - 43,7 mg/l
(OECD Test Guideline 403)
Skin corrosion/irritation
Skin - Rabbit
Result: Irritating to skin. - 4 h
(OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Eye irritation
Remarks: (ECHA)
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative
(OECD Test Guideline 406)
Germ cell mutagenicity
May cause genetic defects.
Ames test
Salmonella typhimurium
Result: negative
Mutagenicity (mammal cell test): chromosome aberration.
Chinese hamster lung cells
Result: positive
In vitro mammalian cell gene mutation test
Result: positive
OECD Test Guideline 474
Mouse - male - Bone marrow
Result: positive Carcinogenicity
May cause cancer. Positive evidence from human epidemiological studies.
IARC: No ingredient of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
Causes damage to organs through prolonged or repeated exposure. - Blood
Aspiration hazard
May be fatal if swallowed and enters airways. Additional Information
Repeated dose toxicity - Rat - male and female - Oral - 120 d - NOAEL (No observed
adverse effect level) - 100 mg/kg - LOAEL (Lowest observed adverse effect level) - 25
mg/kg
Subchronic toxicity
RTECS: Not available
Nausea, Dizziness, Headache, Inhalation of high concentrations of benzene may have an
initial stimulatory effect on the central nervous system characterized by exhilaration,
nervous excitation and/or giddiness, depression, drowsiness, or fatigue. The victim may
experience tightness in the chest, breathlessness, and loss of consciousness. Tremors,
convulsions, and death due to respiratory paralysis or circulatory collapse can occur in a
few minutes to several hours following severe exposures. Aspiration of small amounts of
liquid immediately causes pulmonary edema and hemorrhage of pulmonary tissue. Direct
skin contact may cause erythema. Repeated or prolonged skin contact may result in drying,
scaling dermatitis, or development of secondary skin infections. The chief target organ is
the hematopoietic system. Bleeding from the nose, gums, or mucous membranes and the
development of purpuric spots, pancytopenia, leukopenia, thrombocytopenia, aplastic
anemia, and leukemia may occur as the condition progresses. The bone marrow may
appear normal, aplastic or hyperplastic, and may not correlate with peripheral bloodforming
tissues. The onset of effects of prolonged benzene exposure may be delayed for
many months or years after the actual exposure has ceased., To the best of our
knowledge, the chemical, physical, and toxicological properties have not been thoroughly
investigated.
Systemic effects:
After absorption:
agitation, Headache, Dizziness, inebriation, Tiredness, CNS disorders, narcosis, respiratory
arrest
Subacute toxicity
After a latency period:
Changes in the blood count, haemolysis
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Blood - Irregularities - Based on Human Evidence
ECOLOGICAL INFORMATION12.1 Toxicity
Toxicity to fish flow-through test LC50 - Oncorhynchus mykiss (rainbow trout) - 5,3
mg/l - 96 h
(OECD Test Guideline 203)
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata - 100 mg/l - 72 h
(OECD Test Guideline 201)
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 96 % - Readily biodegradable.
(OECD Test Guideline 301F)
12.3 Bioaccumulative potential
Bioaccumulation Leuciscus idus (Golden orfe) - 3 d - 0,05 mg/l((2H6)benzene)
Bioconcentration factor (BCF): 10
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Other adverse effects
Harmful to aquatic life with long lasting effects.
Endangers drinking-water supplies if allowed to enter soil or water.
Discharge into the environment must be avoided.
DISPOSAL CONSIDERATIONS13.1 Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra
care in igniting as this material is highly flammable. Offer surplus and non-recyclable
solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.
TRANSPORT INFORMATION14.1 UN number
ADR/RID: 1114 IMDG: 1114 IATA: 1114
14.2 UN proper shipping name
ADR/RID: BENZENE, SOLUTION
IMDG: BENZENE, SOLUTION
IATA: Benzene, SOLUTION
14.3 Transport hazard class(es)
ADR/RID: 3 IMDG: 3 IATA: 3
14.4 Packaging group
ADR/RID: II IMDG: II IATA: II
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available
REGULATORY INFORMATION15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
Authorisations and/or restrictions on use
REACH - Restrictions on the manufacture,
placing on the market and use of certain
dangerous substances, preparations and articles
(Annex XVII)
:
REACH - Restrictions on the manufacture,
placing on the market and use of certain
dangerous substances, preparations and articles
(Annex XVII)
:
REACH - Restrictions on the manufacture,
placing on the market and use of certain
dangerous substances, preparations and articles
(Annex XVII)
: (2H6)benzene
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out
OTHER INFORMATIONThe above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. For lab use only!